Mary Gates Research Scholar, Winter 2025
Research Project: Healing the Tiniest Minds: Exploring Azithromycin’s Region-Specific Neonatal Neuroprotection in a Ferret Model of Hypoxic-Ischemic Brain Injury
Project Description: Preterm birth is a leading cause of under-5 mortality and neurological damage. Despite this, there is no standard preventative care or cure. Our lab uses a neonatal ferret model to explore repurposing azithromycin to treat hypoxic-ischemic brain injury in preterm infants.
Using quantitative immunohistochemistry, I analyze cellular markers in key brain regions, such as the cortex, hippocampus, thalamus, and subcortical white matter, to assess the densities of microglia and oligodendrocytes. By mapping where inflammation is reduced, my project aims to clarify whether azithromycin offers region-specific neuroprotection. Our work could lay the foundation for a low-cost, accessible treatment that improves long-term neurological outcomes for preterm infants worldwide.
What have you learned throughout your research project?
Throughout my research experience, I have gained a deep understanding of scientific processes and the persistence required to navigate its complexities. Working on a long-term study involving preterm brain injury, I’ve learned to troubleshoot technical challenges in quantitative immunohistochemistry, manage data across a large sample size, and interpret region-specific differences cell activity and tissue injury. Leading the histology and data analyses components of our study has strengthened my ability to synthesize literature, guide experimental direction, and communicate findings with clarity.
Whether in surgical preparation, post-operative care, or refining data analysis with my mentors, I’ve also learned the value of collaboration. This experience has strengthened my passion for translational neuroscience and shown me that, while research can be challenging, it plays a vital role in driving meaningful clinical progress.
What piece of advice do you have for future applicants?
I would advise future applicants to fully embrace the learning process, including setbacks and breakthroughs. Don’t hesitate to ask questions, take initiative, and advocate for your role in the project. Clarify how your work fits into the bigger picture and focus on your contributions. Be authentic and let your curiosity and commitment to learning shine through in your writing.